Sclerostin is involved in osteogenic transdifferentiation of vascular smooth muscle cells in chronic kidney disease-associated vascular calcification with non-canonical Wnt signaling

Vascular calcification is prominent in patients with chronic kidney disease (CKD) and is a strong predictor of cardiovascular mortality in the CKD population.However, the mechanism underlying CKD-associated vascular calcification remains unclear.To identify potential therapeutic targets, a 5/6 nephrectomy rat model was established by feeding of a h

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Spatial Distribution and Predictive Significance of Dendritic Cells and Macrophages in Esophageal Cancer Treated With Combined Chemoradiotherapy and PD-1 Blockade

BackgroundThe first clinical study (NCT03671265) of first-line chemoradiotherapy combined with PD-1 blockade showed promising 12n/1200 wella treatment outcomes in locally advanced esophageal squamous cell carcinoma (ESCC).However, partial patients did not respond to the combination treatment.The roles of dendritic cells (DCs) and macrophages in thi

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A novel reduced graphene oxide decorated with halloysite nanotubes (HNTs-d-rGO) hybrid composite and its flame-retardant application for polyamide 6

The improvement of flame-retardant properties of polyamide 6 (PA6) was achieved by using reduced graphene oxide decorated with halloysite nanotubes (HNTs-d-rGO) hybrid composite as the additive in PA6 matrix.The intimate integration of reduced graphene oxide (rGO) and halloysite nanotubes (HNTs) through a three-step chemical functionalization, mits

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